LNME.AO

Metronidazol

Prescription Hospital MunicipalHospital Geral e/ou Especializado

Overview

National code
28-28001RP
UNSPSC
51282810
Composition
125mg/5ml (benzoato)
Presentation
suspensão oral
Prescription
Required
Levels of care
Hospital Municipal, Hospital Geral e/ou Especializado
ATC code
J01XD01

Dose calculator

Estimate from the rules recorded for this medicine. Always confirm before prescribing.

⚠️ The calculator is an aid: always confirm the dose against your local clinical protocol. Rules marked “pending review” have not yet been validated by a pharmacist or doctor.

Safety and references

  • The result is a calculation aid, not a prescription: check it against the leaflet, the local protocol or a pharmacist.
  • Obese patients: a per-kg dose may call for ideal or adjusted weight, not actual weight.
  • Renal or hepatic impairment may require adjusting the dose or the interval.
  • Chemotherapy and other narrow-margin drugs only with a specialist.
  • Check the units (mg or mcg, IU, ml) and that the weight is plausible before giving the drug.

References

  1. Bates DW, et al. Incidence of adverse drug events and potential adverse drug events. JAMA. 1995;274(1):29-34.
  2. Merry AF, Anderson BJ. Medication errors — new approaches to prevention. Paediatr Anaesth. 2011;21(7):743-753.

Interactions

  • Grave Warfarina

    Clinical effect: Metronidazol inibe CYP2C9, aumentando os níveis plasmáticos de warfarina e o risco hemorrágico.

    Recommendation: Monitorizar INR com frequência. Reduzir dose de warfarina em 25–50%.

    Source: BNF / Goodman & Gilman

  • Moderada Lítio

    Clinical effect: O metronidazol pode aumentar as concentrações de lítio.

    Recommendation: Vigiar a litemia.

    Source: BNF

  • Moderada Fenobarbital

    Clinical effect: O fenobarbital reduz as concentrações de metronidazol.

    Recommendation: Vigiar a resposta ao tratamento.

    Source: BNF

  • Moderada Fenitoína

    Clinical effect: O metronidazol aumenta as concentrações de fenitoína.

    Recommendation: Vigiar sinais de toxicidade da fenitoína.

    Source: BNF

  • Moderada Etanol

    Clinical effect: Pode causar uma reação tipo dissulfiram (rubor, náuseas, vómitos, taquicardia).

    Recommendation: Evitar álcool durante o tratamento e até 48 horas depois.

    Source: BNF

  • Moderada Morfina

    Clinical effect: Metronidazol pode inibir o CYP3A4 e aumentar os níveis de morfina.

    Recommendation: Monitorizar resposta à morfina. Ajustar dose se necessário.

    Source: BNF

⚠️ The drug-interaction analysis in LNME.AO is for information only and does not replace clinical or pharmaceutical validation by a professional.

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