LNME.AO

Fluconazol

Prescription Centro de SaúdeHospital MunicipalHospital Geral e/ou Especializado

Overview

National code
30-34007RS
UNSPSC
51303402
Composition
150 mg
Presentation
cápsula
Prescription
Required
Levels of care
Centro de Saúde, Hospital Municipal, Hospital Geral e/ou Especializado
ATC code
J02AC01

Dose calculator

Estimate from the rules recorded for this medicine. Always confirm before prescribing.

⚠️ The calculator is an aid: always confirm the dose against your local clinical protocol. Rules marked “pending review” have not yet been validated by a pharmacist or doctor.

Safety and references

  • The result is a calculation aid, not a prescription: check it against the leaflet, the local protocol or a pharmacist.
  • Obese patients: a per-kg dose may call for ideal or adjusted weight, not actual weight.
  • Renal or hepatic impairment may require adjusting the dose or the interval.
  • Chemotherapy and other narrow-margin drugs only with a specialist.
  • Check the units (mg or mcg, IU, ml) and that the weight is plausible before giving the drug.

References

  1. Bates DW, et al. Incidence of adverse drug events and potential adverse drug events. JAMA. 1995;274(1):29-34.
  2. Merry AF, Anderson BJ. Medication errors — new approaches to prevention. Paediatr Anaesth. 2011;21(7):743-753.

Interactions

  • Grave Lumefantrina

    Clinical effect: Aumenta o risco de prolongamento do intervalo QT e as concentrações de lumefantrina.

    Recommendation: Evitar. Se for essencial, monitorizar o ECG.

    Source: ficha da arteméter/lumefantrina

  • Grave Metadona

    Clinical effect: O fluconazol aumenta as concentrações de metadona e o risco de prolongamento do QT.

    Recommendation: Reduzir a dose de metadona e monitorizar o ECG.

    Source: BNF

  • Grave Gliclazida

    Clinical effect: O fluconazol aumenta o efeito da gliclazida, com risco de hipoglicemia grave.

    Recommendation: Evitar ou reduzir a dose e vigiar a glicemia.

    Source: BNF

  • Grave Amiodarona

    Clinical effect: Aumenta o risco de prolongamento do intervalo QT e de arritmias graves.

    Recommendation: Evitar. Se for essencial, monitorizar o ECG e os eletrólitos.

    Source: BNF

  • Grave Midazolam

    Clinical effect: O fluconazol aumenta as concentrações de midazolam, com sedação prolongada.

    Recommendation: Reduzir a dose de midazolam e vigiar a sedação.

    Source: BNF

  • Grave Fenitoína

    Clinical effect: O fluconazol aumenta muito as concentrações de fenitoína, com risco de toxicidade.

    Recommendation: Vigiar sinais de toxicidade e as concentrações de fenitoína.

    Source: BNF / Stockley

  • Grave Rifampicina

    Clinical effect: Rifampicina induz o metabolismo do fluconazol, reduzindo seus níveis e eficácia antifúngica.

    Recommendation: Monitorizar eficácia clínica. Pode ser necessário aumentar a dose de fluconazol.

    Source: BNF / WHO

  • Grave Carbamazepina

    Clinical effect: Fluconazol inibe CYP3A4, aumentando os níveis de carbamazepina.

    Recommendation: Monitorizar nível sérico de carbamazepina. Reduzir dose se necessário.

    Source: BNF

  • Grave Sinvastatina

    Clinical effect: Fluconazol inibe CYP3A4 e CYP2C9, aumentando os níveis de sinvastatina.

    Recommendation: Suspender sinvastatina durante tratamento com fluconazol, ou usar alternativa.

    Source: BNF / Goodman & Gilman

  • Grave Warfarina

    Clinical effect: Fluconazol é potente inibidor do CYP2C9, elevando significativamente os níveis de warfarina.

    Recommendation: Monitorizar INR muito frequentemente. Reduzir dose de warfarina. Considerar alternativa antifúngica.

    Source: BNF / Goodman & Gilman

  • Moderada Zidovudina

    Clinical effect: O fluconazol aumenta as concentrações de zidovudina.

    Recommendation: Vigiar o hemograma e sinais de toxicidade.

    Source: Liverpool HIV Drug Interactions

  • Moderada Nevirapina

    Clinical effect: O fluconazol aumenta as concentrações de nevirapina e o risco de toxicidade hepática.

    Recommendation: Vigiar as enzimas hepáticas.

    Source: Liverpool HIV Drug Interactions

  • Moderada Haloperidol

    Clinical effect: Aumenta o risco de prolongamento do intervalo QT.

    Recommendation: Monitorizar o ECG.

    Source: BNF

  • Moderada Ciclosporina

    Clinical effect: O fluconazol aumenta as concentrações de ciclosporina.

    Recommendation: Monitorizar as concentrações de ciclosporina e a função renal.

    Source: BNF

⚠️ The drug-interaction analysis in LNME.AO is for information only and does not replace clinical or pharmaceutical validation by a professional.

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